Income Taxes (Details) (USD $)	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Income Tax Disclosure [Line Items]
Income tax provision (benefit)	$ (1,169,000)	$ (2,242,000)	$ 3,348,000
Undistributed Earnings of Foreign Subsidiaries	138,300,000
Deferred tax assets, change in valuation allowance	3,400,000	4,400,000	(7,700,000)
Federal Net operating loss carryforwards	110,300,000
Research and development, orphan drug and investment tax credit carryforwards gross amount	12,200,000
State net operating loss carryforwards	26,900,000
State research and development tax credit carryforwards	2,200,000
Valuation allowance related to stock option deductions	3,700,000
Unrecognized tax benefits	5,876,000	6,138,000	6,053,000	5,715,000
Unrecognized tax benefits that would impact effective tax rate	2,200,000
Unrecognized tax benefits, amount offset by valuation allowance	3,700,000
Promotion And Distribution Contract Rights [Member]
Income Tax Disclosure [Line Items]
Income tax provision (benefit)			6,800,000
Impairment of intangible asset			$ 42,700,000
China [Member]
Income Tax Disclosure [Line Items]
Statutory income tax rate	25.00%	25.00%	25.00%
Income tax examination, period	5 years