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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
 WPxbBhCrNYQV9iMTT7a7/No27yXb7jQkHec6Kn+FlzegHPb0XhH7am4LBcFL6g+u
 5OB0YP3dDd5LoYOG0hLluQ==

<SEC-DOCUMENT>0001214659-05-000716.txt : 20050520
<SEC-HEADER>0001214659-05-000716.hdr.sgml : 20050520
<ACCEPTANCE-DATETIME>20050520163648
ACCESSION NUMBER:		0001214659-05-000716
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050518
FILED AS OF DATE:		20050520
DATE AS OF CHANGE:		20050520

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			DENDRITE INTERNATIONAL INC
		CENTRAL INDEX KEY:			0000880321
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-PREPACKAGED SOFTWARE [7372]
		IRS NUMBER:				222786386
		STATE OF INCORPORATION:			NJ
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1405/1425 ROUTE 206 SOUTH
		CITY:			BEDMINSTER
		STATE:			NJ
		ZIP:			07921
		BUSINESS PHONE:		9084432000

	MAIL ADDRESS:	
		STREET 1:		1405/1425 ROUTE 206 SOUTH
		CITY:			BEDMINSTER
		STATE:			NJ
		ZIP:			07921

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ZAFFARONI PAUL L
		CENTRAL INDEX KEY:			0001192127

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-16379
		FILM NUMBER:		05848650

	BUSINESS ADDRESS:	
		STREET 1:		C/O DONDRITE INTERNATIONAL INC
		STREET 2:		200 SOMERSET CORP BLVD
		CITY:			BRIDGEWATER
		STATE:			NJ
		ZIP:			08807
		BUSINESS PHONE:		9084432000

	MAIL ADDRESS:	
		STREET 1:		C/O DENDRITE INTERNATIONAL INC
		STREET 2:		1405/1425 ROUTE 206 SOUTH
		CITY:			BEDMINSTER
		STATE:			NJ
		ZIP:			07921
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>f51858f4_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-05-18</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000880321</issuerCik>
        <issuerName>DENDRITE INTERNATIONAL INC</issuerName>
        <issuerTradingSymbol>DRTE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001192127</rptOwnerCik>
            <rptOwnerName>ZAFFARONI PAUL L</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O DENDRITE INTERNATIONAL INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1405 ROUTE 206 SOUTH</rptOwnerStreet2>
            <rptOwnerCity>BEDMINSTER</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>07921</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President &amp; COO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Options to Purchase Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>13.87</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2005-05-18</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>85000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2005-05-18</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>85000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>85000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Stock options will vest on December 31, 2005, however, the right to sell the underlying shares accrues only in one-third
annual increments commencing on the vesting date.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Paul L. Zaffaroni</signatureName>
        <signatureDate>2005-05-19</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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