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Note 12 - Summary of Stock Options (Details Textual) - USD ($)												1 Months Ended											7 Months Ended	12 Months Ended
	Dec. 31, 2019	Sep. 30, 2019	Jun. 28, 2019	Mar. 29, 2019	Dec. 31, 2018	Sep. 28, 2018	Jun. 29, 2018	May 30, 2018	Mar. 29, 2018	Aug. 31, 2017	Aug. 22, 2016	Sep. 30, 2019	Jul. 31, 2019	Jun. 30, 2019	Apr. 30, 2019	Jan. 31, 2019	Dec. 31, 2018	Oct. 30, 2018	Jul. 31, 2018	Jun. 30, 2018	Apr. 30, 2018	Jan. 31, 2018	Dec. 31, 2019	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017	Nov. 26, 2019	Jan. 01, 2019	Jan. 01, 2018
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance	10,087,678				40,144												40,144						10,087,678	10,087,678	40,144	26,903
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance	$ 2.22				$ 455.68												$ 455.68						$ 2.22	$ 2.22	$ 455.68	$ 579.81
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term																								9 years 328 days	7 years 146 days	8 years 219 days
Stock Issued During Period, Shares, Restricted Stock Award, Gross																				1,000
Shares Issued, Price Per Share																				$ 2.56
Proceeds from Stock Plans																								$ 56,000	$ 233,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross																								10,065,844	23,542
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate																								0.00%	0.00%
Director [Member]
Stock Issued During Period, Shares, Restricted Stock Award, Gross													378		525
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period															525
Consultant [Member]
Stock Issued During Period, Shares, Restricted Stock Award, Gross														250
Nonemployees [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate																								0.00%	0.00%
Share-based Payment Arrangement, Option [Member]
Share-based Payment Arrangement, Accelerated Cost								$ 97,000
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate																								0.00%
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total	$ 7,640,000																						$ 7,640,000	$ 7,640,000
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition																								3 years 109 days
Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number, Ending Balance	2,640																						2,640	2,640
Restricted Stock [Member] \| Director [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value													$ 38.08		$ 91
The 2006 Stock Option Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance	104																						104	104
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant	0																						0	0
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance	$ 992																						$ 992	$ 992
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term																								3 years 36 days
The 2013 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance	10,087,574																						10,087,574	10,087,574
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant	1,798,337																						1,798,337	1,798,337
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance	$ 2.21																						$ 2.21	$ 2.21
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term																								9 years 328 days
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period																								10 years
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period																								4 years
Share-based Compensation Arrangement by Share-based Payment Award, Percentage of Outstanding Stock Maximum																								10.00%
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent																								110.00%
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized, Percentage Increase of Outstanding Common Stock											4.00%
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized	11,872,531				49,140												49,140						11,872,531	11,872,531	49,140	40,000	11,872,531	69,571	49,140
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized																20,431
Common Stock Shares Reserved For Future Issuance Percentage		18.00%										18.00%
The 2013 Plan [Member] \| Employees [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross																								9,528,869	21,419
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value																								$ 0.73	$ 224.35
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period																								0	0
The 2013 Plan [Member] \| Nonemployees [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross																								536,975	2,123
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value																								$ 0.61	$ 162.17
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period																								0	0
The 2013 Plan [Member] \| Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period																3,625
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period																								1,255
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period																								0
The 2013 Plan [Member] \| Restricted Stock [Member] \| Director [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value													$ 38.08		$ 91		$ 105	$ 248	$ 263		$ 344	$ 519
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period													378		525		407	178	181		144	943
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period													378		525		407	178	182		144	94
The 2013 Plan [Member] \| Restricted Stock [Member] \| Consultant [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period																				2 years		1 year
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value																				$ 358		$ 497
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period																				500		250
The 2013 Plan [Member] \| Restricted Stock [Member] \| Consultant [Member] \| June 2018 [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period																							250
The 2013 Plan [Member] \| Restricted Stock [Member] \| Consultant [Member] \| January 2018 [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period																									250
The 2013 Plan [Member] \| Underwritten Public Offering [Member]
Minimum Gross Proceeds From Equity Offering Amount Used In Calculation Of Reserved Shares Percentage												$ 5,000,000
The 2013 Plan [Member] \| Holdings Greater Than 10 Percent of Shares Outstanding [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period																								5 years
2017 Employee Stock Purchase Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent										85.00%
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Number of Shares Per Employee										200
Stock Issued During Period, Shares, Employee Stock Purchase Plans	300	200	602	429	494	274	243		198															1,531	1,209
Shares Issued, Price Per Share	$ 1.07	$ 3.75	$ 32.30	$ 79.88	$ 89.25	$ 223.55	$ 231.20		$ 311.10			$ 3.75					$ 89.25						$ 1.07	$ 1.07	$ 89.25
Proceeds from Stock Plans																								$ 233,000	$ 56,000
Employee Stock Ownership Plan (ESOP), Number of Suspense Shares	1,092																						1,092	1,092
Employee Stock Ownership Plan (ESOP), Weighted Average Purchase Price of Shares Purchased																								$ 22.75	$ 89
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate																								0.00%	0.00%