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Note 2 - Summary of Significant Accounting Policies - Antidilutive Securities (Details) - shares
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Employee Stock Option [Member]    
Antidilutive Securities Excluded from Computation of Earnings Per Share (in shares) 8,177,291 2,291,783
Common Stock Warrants [Member]    
Antidilutive Securities Excluded from Computation of Earnings Per Share (in shares) 3,066,447 1,793,887
Rights to Shares [Member]    
Antidilutive Securities Excluded from Computation of Earnings Per Share (in shares)   566,038