Note 9 - Summary of Stock Options - Summary of Options Outstanding and Exercisable (Details)	12 Months Ended
Dec. 31, 2015 $ / shares shares
Range One [Member]
Range of Exercise Prices (in dollars per share)	$ 0.33
Options Outstanding, Number (in shares) \| shares	100,000
Options Outstanding - Weighted Average Exercise Price (in dollars per share)	$ 0.33
Options Outstanding - Weighted Average Remaining Contractual Term	9 years 135 days
Options Exercisable - Number (in shares) \| shares
Options Exercisable - Weighted Average Exercise Price (in dollars per share)
Range Two [Member]
Range of Exercise Prices (in dollars per share)	$ 0.47
Options Outstanding, Number (in shares) \| shares	635,000
Options Outstanding - Weighted Average Exercise Price (in dollars per share)	$ 0.47
Options Outstanding - Weighted Average Remaining Contractual Term	9 years 40 days
Options Exercisable - Number (in shares) \| shares
Options Exercisable - Weighted Average Exercise Price (in dollars per share)
Range of Exercise Prices, Lower Range (in dollars per share)	$ 0.46
Range of Exercise Prices, Upper Range (in dollars per share)	0.47
Range Three [Member]
Range of Exercise Prices (in dollars per share)	$ 0.60
Options Outstanding, Number (in shares) \| shares	1,768,980
Options Outstanding - Weighted Average Exercise Price (in dollars per share)	$ 0.60
Options Outstanding - Weighted Average Remaining Contractual Term	8 years 200 days
Options Exercisable - Number (in shares) \| shares	585,542
Options Exercisable - Weighted Average Exercise Price (in dollars per share)	$ 0.60
Range Four [Member]
Range of Exercise Prices (in dollars per share)	$ 0.75
Options Outstanding, Number (in shares) \| shares	4,949,004
Options Outstanding - Weighted Average Exercise Price (in dollars per share)	$ 0.75
Options Outstanding - Weighted Average Remaining Contractual Term	9 years 354 days
Options Exercisable - Number (in shares) \| shares
Options Exercisable - Weighted Average Exercise Price (in dollars per share)
Range Five [Member]
Range of Exercise Prices (in dollars per share)	$ 0.96
Options Outstanding, Number (in shares) \| shares	335,000
Options Outstanding - Weighted Average Exercise Price (in dollars per share)	$ 0.96
Options Outstanding - Weighted Average Remaining Contractual Term	9 years 219 days
Options Exercisable - Number (in shares) \| shares
Options Exercisable - Weighted Average Exercise Price (in dollars per share)
Range of Exercise Prices, Lower Range (in dollars per share)	$ 0.89
Range of Exercise Prices, Upper Range (in dollars per share)	0.99
Range Six [Member]
Range of Exercise Prices (in dollars per share)	$ 1.24
Options Outstanding, Number (in shares) \| shares	312,373
Options Outstanding - Weighted Average Exercise Price (in dollars per share)	$ 1.24
Options Outstanding - Weighted Average Remaining Contractual Term	6 years 288 days
Options Exercisable - Number (in shares) \| shares	312,373
Options Exercisable - Weighted Average Exercise Price (in dollars per share)	$ 1.24
Range Seven [Member]
Range of Exercise Prices (in dollars per share)	$ 8.64
Options Outstanding, Number (in shares) \| shares	57,603
Options Outstanding - Weighted Average Exercise Price (in dollars per share)	$ 8.64
Options Outstanding - Weighted Average Remaining Contractual Term	1 year 222 days
Options Exercisable - Number (in shares) \| shares	57,603
Options Exercisable - Weighted Average Exercise Price (in dollars per share)	$ 8.64
Range of Exercise Prices, Lower Range (in dollars per share)	7
Range of Exercise Prices, Upper Range (in dollars per share)	9
Range Eight [Member]
Range of Exercise Prices (in dollars per share)	$ 15.29
Options Outstanding, Number (in shares) \| shares	19,081
Options Outstanding - Weighted Average Exercise Price (in dollars per share)	$ 15.29
Options Outstanding - Weighted Average Remaining Contractual Term	1 year 273 days
Options Exercisable - Number (in shares) \| shares	19,081
Options Exercisable - Weighted Average Exercise Price (in dollars per share)	$ 15.29
Range of Exercise Prices, Lower Range (in dollars per share)	12
Range of Exercise Prices, Upper Range (in dollars per share)	18.63
Range Nine [Member]
Range of Exercise Prices (in dollars per share)	$ 37
Options Outstanding, Number (in shares) \| shares	250
Options Outstanding - Weighted Average Exercise Price (in dollars per share)	$ 37
Options Outstanding - Weighted Average Remaining Contractual Term	1 year 266 days
Options Exercisable - Number (in shares) \| shares	250
Options Exercisable - Weighted Average Exercise Price (in dollars per share)	$ 37
Range of Exercise Prices (in dollars per share)	$ 0.81
Options Outstanding, Number (in shares) \| shares	8,177,291
Options Outstanding - Weighted Average Exercise Price (in dollars per share)	$ 0.81
Options Outstanding - Weighted Average Remaining Contractual Term	9 years 135 days
Options Exercisable - Number (in shares) \| shares	974,849
Options Exercisable - Weighted Average Exercise Price (in dollars per share)	$ 1.58

The floor of a customized range of exercise prices for purposes of disclosing shares potentially issuable under outstanding stock option awards on all stock option plans and other required information pertaining to awards in the customized range.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (g)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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The number of shares reserved for issuance pertaining to the outstanding exercisable stock options as of the balance sheet date in the customized range of exercise prices for which the market and performance vesting condition has been satisfied.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(iii)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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- Definition

The number of shares reserved for issuance pertaining to the outstanding stock options as of the balance sheet date for all option plans in the customized range of exercise prices.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(i)-(ii)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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- Definition

The ceiling of a customized range of exercise prices for purposes of disclosing shares potentially issuable under outstanding stock option awards on all stock option plans and other required information pertaining to awards in the customized range.

+ References

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- Definition

Weighted average exercise price as of the balance sheet date for those equity-based payment arrangements exercisable and outstanding.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(iii)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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- Definition

The weighted average price as of the balance sheet date at which grantees could acquire the underlying shares with respect to all outstanding stock options which are in the customized range of exercise prices.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(i)-(ii)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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- Definition

Weighted average remaining contractual term of outstanding stock options, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (e)(1)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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