Note 10 - Summary of Stock Options (Tables)

9 Months Ended

12 Months Ended

Sep. 30, 2014

Dec. 31, 2013

Note 10 - Summary of Stock Options (Tables) [Line Items]

Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]

	Outstanding Options
						Weighted
				Weighted		Average
	Number			Average		Remaining
	of			Exercise		Contractual
	Shares			Price		Term (years)
Options outstanding as of December 31, 2013		363,413		$	2.94		8.80
Options granted		1,901,476		$	0.60
Options assumed from PLC		68,238		$	10.24
Options canceled		(38,593	)	$	1.75
Options outstanding as of September 30, 2014		2,294,534		$	1.02		9.67

				Outstanding Options
									Weighted
	Shares						Weighted		Average
	Available			Number			Average		Remaining
	for			of			Exercise		Contractual
	Grant			Shares			Price		Term (years)
Shares reserved at plan inception		1,000,000			-		$	-
Options granted		(51,500	)		51,500			0.001
Balances as of December 31, 2006		948,500			51,500			0.001		9.96
Additional shares reserved		2,000,000			-			-
Options granted		(867,000	)		867,000			0.06
Options forfeited		5,000			(5,000	)		0.001
Balances as of December 31, 2007		2,086,500			913,500			0.06		9.82
Options granted		(72,500	)		72,500			0.06
Balances as of December 31, 2008		2,014,000			986,000			0.06		8.87
Options granted		(1,892,029	)		1,892,029			0.06
Options exercised		-			(322,395	)		0.06
Options forfeited		377,605			(377,605	)		0.06
Balances as of December 31, 2009		499,576			2,178,029			0.06		9.00
Additional shares reserved		461,957			-			-
Options granted		(771,412	)		771,412			0.05
Options exercised		-			(173,455	)		0.001
Options forfeited		12,500			(12,500	)		0.06
Balances as of December 31, 2010		202,621			2,763,486			0.06		8.40
Additional shares reserved		500,000			-			-
Options granted		(345,000	)		345,000			0.12
Options exercised		-			(9,000	)		0.001
Options forfeited		139,000			(139,000	)		0.06
Repurchase of restricted stock options		5,250			-
Balances as of December 31, 2011		501,871			2,960,486			0.07		7.70
Additional shares reserved		80,000,000			-			-
Options granted		(43,694,521	)		43,694,521			0.01
Options exercised		-			(1,866,903	)		0.07
Balances as of December 31, 2012		36,807,350			44,788,104			0.01		9.74
Options granted		(11,873,890	)		11,873,890			0.01
Options cancelled		11,515,876			(11,515,876	)		0.01
Balances as of December 31, 2013		36,449,336			45,146,118		$	0.01		8.80
Options vested and expected to vest as of December 31, 2013					43,338,910		$	0.01		8.80
Options vested as of December 31, 2013					15,025,985		$	0.02		8.60

Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block]

			Options Outstanding						Options Exercisable
							Weighted
			Number		Weighted		Average		Number		Weighted
			Outstanding		Average		Remaining		Exercisable		Average
Range of			as of		Exercise		Contractual		as of		Exercise
Exercise Prices			September 30, 2014		Price		Term (Years)		September 30, 2014		Price
	$0.12			320	$	0.12		2.21		320	$	0.12
	$0.60			1,901,476	$	0.60		10.00		20,000	$	0.60
	$1.24			314,036	$	1.24		8.15		314,036	$	1.24
$7.00	-	$9.00		59,372	$	8.63		8.28		59,372	$	8.63
$12.00	-	$18.63		19,081	$	15.29		6.79		19,081	$	15.29
	$37.00			250	$	37.00		3.72		250	$	37.00
				2,294,535	$	1.02		9.67		413,059	$	2.94

		Options Outstanding				Options Vested
				Weighted
				Average				Weighted
				Remaining				Average
Exercise		Number		Contractual		Number		Exercise
Price		Outstanding		Life (Years)		of Options		Price
$	0.001		40,000		2.95		40,000	$	0.001
	0.06		980,250		5.68		921,104		0.06
	0.15		514,833		7.94		447,055		0.15
	0.01		43,611,035		8.89		13,617,826		0.01
			45,146,118		8.80		15,025,985	$	0.02

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

	Nine Months Ended
	September 30,
	2014		2013
Expected term (in years)		5		5
Average volatility		61%		67%
Risk-free interest rate		1.80%		0.87%
Dividend yield		0%		0%

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

	Three Months Ended September 30,				Nine Months Ended September 30,
	2014		2013		2014		2013
Research and development	$	101	$	976	$	667	$	(7,016	)
General and administrative		113,245		15,308		142,976		73,017
Total	$	113,346	$	16,284	$	143,643	$	66,001

Employee Stock Option [Member]

Note 10 - Summary of Stock Options (Tables) [Line Items]

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

							Cumulative for the Period
							September 21, 2005
							(Date of Inception) to
	2012			2013			December 31, 2013
Expected term (in years)		5.00			5.00			5.00 - 6.25
Expected volatility		68	%		67	%		60% - 79	%
Risk-free interest rate		0.76% - 0.84	%		0.84	%		0.76% - 4.7	%
Dividend yield		0	%		0	%		0	%

Nonemployee Stock Option [Member]

Note 10 - Summary of Stock Options (Tables) [Line Items]

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

					Cumulative for the Period
					September 21, 2005
					(Date of Inception) to
	2012		2013		December 31, 2013
Contractual term (in years)		4 - 10		3 - 10		3 - 10
Expected volatility		68%		67%		60% - 79%
Risk-free interest rate		0.72% - 1.78%		0.78% - 3.04%		0.56% - 4.7%
Dividend yield		0%		0%		0%