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Organization and Significant Accounting Policies - Narrative (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 9 Months Ended
Jul. 27, 2025
Feb. 24, 2025
Feb. 07, 2025
Nov. 25, 2024
Jun. 30, 2025
Mar. 31, 2025
Jun. 30, 2024
Jun. 30, 2025
Jun. 30, 2024
Sep. 30, 2024
Sep. 30, 2023
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                      
Cash, cash equivalents and restricted cash         $ 129,793   $ 69,399 $ 129,793 $ 69,399 $ 102,685 $ 110,891
Restricted cash         2,200     2,200      
Available-for-sale securities         770,579     770,579   $ 578,276  
Increase (decrease) in cash and investments               219,400      
Proceeds from the issuance of warrants       $ 25,000       25,000 0    
Repayments of credit facility               201,625 0    
Interest income         11,019   $ 6,498 28,236 $ 15,550    
Development regulatory and sales milestones payments         $ 13,300,000     $ 13,300,000      
Sarepta | Sarepta Collaboration Agreement                      
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                      
Proceeds from sale of stock     $ 325,000                
Shares of common stock issued (in shares)     11,926,301                
Common stock sold price (in dollars per share)     $ 27.25                
Upfront payment   $ 500,000                  
Annual fees     $ 250,000                
Annual installments period     5 years                
Enrollment related milestone payments     $ 300,000                
Future potential milestone payments     $ 10,000,000                
Sarepta | Sarepta Collaboration Agreement | Subsequent Event                      
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                      
Development milestone payments $ 100,000                    
Future potential milestone payments $ 200,000                    
GSK | GSK-HBV Agreement                      
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]                      
Development milestone payments           $ 2,500