Collaboration and License Agreements - Joint Venture and License Agreement with Visirna Therapeutics, Inc. (Details) - USD ($) $ in Thousands		3 Months Ended
	Apr. 25, 2022	Dec. 31, 2022	Dec. 31, 2021	Sep. 30, 2022
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Proceeds from the sale of future royalties		$ 250,000	$ 0
Revenue		62,546	$ 27,439
Deferred revenue		66,281		$ 74,099
Visirna Therapeutics, Inc. | Visirna License Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenue		700
Contract assets		0
Deferred revenue		$ 0
Visirna Therapeutics, Inc. | Visirna License Agreement | Variable Interest Entity, Primary Beneficiary
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Proceeds from the sale of future royalties	$ 60,000