Collaboration and License Agreements - Horizon Therapeutics Ireland DAC (Details)		3 Months Ended
	Jun. 18, 2021 USD ($) obligation bundle	Mar. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Sep. 30, 2022 USD ($)	Jul. 31, 2021 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development regulatory and sales milestones payments			$ 4,100,000,000
Revenues			62,546,000	$ 27,439,000
Contract liabilities			66,281,000		$ 74,099,000
Horizon Therapeutics Ireland DAC | Subsequent Event
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront milestone payment received		$ 15,000,000
Horizon Therapeutics Ireland DAC | ARO-XDH
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Cash received as due under collaboration agreement						$ 40,000,000
Number of distinct performance obligations | obligation	1
Initial transaction price	$ 40,000,000
Revenues			21,700,000	$ 6,700,000
Contract assets			15,000,000
Contract liabilities			$ 0
Horizon Therapeutics Ireland DAC | License Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Number of distinct bundle | bundle	1
Number of distinct performance obligations | obligation	1
Horizon Therapeutics Ireland DAC | Maximum | ARO-XDH
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development regulatory and sales milestones payments	$ 660,000,000