Organization and Significant Accounting Policies - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Dec. 31, 2022	Sep. 30, 2022
Organization And Significant Accounting Policies [Line Items]
Cash, cash equivalents and restricted cash		$ 202,200
Restricted cash		7,300
Short term investments		299,582	$ 268,391
Long-term investments		115,774	$ 105,872
Increase in cash and investments		135,300
Development regulatory and sales milestones payments		4,100,000
Horizon Therapeutics Ireland DAC | Subsequent Event
Organization And Significant Accounting Policies [Line Items]
Upfront milestone payment received	$ 15,000
Amgen | Subsequent Event
Organization And Significant Accounting Policies [Line Items]
Upfront milestone payment received	$ 25,000
Royalty Pharma
Organization And Significant Accounting Policies [Line Items]
Upfront milestone payment received		$ 250,000