X0306 4 2021-06-22 0 0000879407 ARROWHEAD PHARMACEUTICALS, INC. ARWR 0001156207 GIVEN DOUGLAS B 177 E. COLORADO BLVD SUITE 700 PASADENA CA 91105 1 0 0 0 Common Stock 2021-06-22 4 S 0 4500 89.21 D 114868 D Common Stock 13875 I By Trust Common Stock 12500 I By Trust The price reported on Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $88.90 to $89.38, inclusive. The reporting person undertakes to provide to Arrowhead Pharmaceuticals, Inc., any security holder of Arrowhead Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote of this Form 4. Includes previously reported shares of common stock underlying Restricted Stock Units granted to the Reporting person which are subject to certain vesting conditions. Represents securities owned directly by Anne Given Trust ("AG Trust"). Mr. Given, as co-trustee of AG Trust, may be deemed to beneficially own the securities owned directly by AG Trust. Represents securities owned directly by Katherine Given Ligtenberg Trust ("KGL Trust"). Mr. Given, as co-trustee of KGL Trust, may be deemed to beneficially own the securities owned directly by KGL Trust. /s/Douglass Given 2021-06-24