X0306 4 2019-02-15 0 0000879407 ARROWHEAD PHARMACEUTICALS, INC. ARWR 0001219384 GIVEN BRUCE D 225 S. LAKE AVENUE SUITE 1050 PASADENA CA 91101 0 1 0 0 Chief Operating Officer Common Stock 2019-02-15 4 S 0 26250 17.67 D 644606 D Common Stock 2019-02-19 4 M 0 42500 2.01 A 687106 D Common Stock 2019-02-19 4 S 0 42500 17.98 D 644606 D Stock Option (right to buy) 2.01 2019-02-19 4 M 0 42500 0.00 D 2013-06-01 2023-05-06 Common Stock 42500 435000 D Open market sale pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The price reported on Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $17.61 to $17.79, inclusive. The reporting person undertakes to provide to Arrowhead Pharmaceuticals, Inc., any security holder of Arrowhead Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote of this Form 4. The price reported on Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $17.98 to $18.00, inclusive. The reporting person undertakes to provide to Arrowhead Pharmaceuticals, Inc., any security holder of Arrowhead Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote of this Form 4. Represents first vesting date. Option vested over four years from date of grant. /s/ Bruce Given 2019-02-20