Statement of Cash Flow (Parenthetical) (Detail) (USD $)		1 Months Ended
	Apr. 23, 2008	Oct. 21, 2011 Roche [Member]	Apr. 05, 2012 Alvos acquisition [Member]	Mar. 23, 2005 Insert Therapeutics, Inc [Member]	Feb. 28, 2010 Calando Pharmaceuticals, Inc. [Member]	Nov. 30, 2009 Calando Pharmaceuticals, Inc. [Member]	Mar. 31, 2006 Calando Pharmaceuticals, Inc. [Member]	Sep. 30, 2010 Calando Pharmaceuticals, Inc. [Member] Series A Preferred Stock [Member]	Apr. 29, 2008 MASA Energy LLC [Member]
Purchase of common shares	200,000			7,375,000	200,000	2,850,000	964,000	1,562.5
Common stock, shares issued	7,054			50,226	8,000	114,000	20,838		10,504
Common stock value				$ 2,000,000		$ 706,800	$ 1,077,333		$ 310,000
Value of common stock purchased							1,928,000		560,000
Stock purchased by cash	200,000						850,667		250,000
Warrants issued					2,400	24,000		390,625
Warrants purchased					60,000	600,000
Common stock exercise value					$ 5.00			$ 5.00
Shares exchanged as part of acquisition		1,288,158	315,457
Issue of promissory note to Roche		$ 50,000