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Collaboration and License Agreements - Amgen, Inc. (Details)	Dec. 31, 2025 USD ($)	Sep. 30, 2025 USD ($)	Dec. 31, 2024 USD ($)	Sep. 30, 2016 agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Contract assets	$ 9,827,000	$ 0	$ 0
Contract liabilities included in deferred revenue, current	111,933,000	$ 2,399,000	$ 0
Amgen Incorporated \| Olpasiran Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Number of agreements \| agreement				2
Contract assets	0
Contract liabilities included in deferred revenue, current	0
Amgen Incorporated \| Olpasiran Agreement \| Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Additional remaining development regulatory and sales milestones payments	$ 485,000,000