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Insider Trading Arrangements
 3 Months Ended
Sep. 30, 2025
shares
Trading Arrangements, by Individual  
Material Terms of Trading Arrangement
During the fiscal quarter ended September 30, 2025, the following directors and officers (as defined in Exchange Act Rule 16a-1(f)) adopted certain trading plans intended to satisfy Rule 10b5-1(c):
NameTitleAdoption or Termination DatePlan End Date
Shares Vesting and Subject to Sell-To-Cover (1)
Other Shares Being Sold (Subject to Certain Conditions)
Adeoye OlukotunBoard Member09/04/202512/24/2025n/a10,000
Christopher AnzalonePresident and Chief Executive Officer09/19/202512/24/202650,000n/a
Daniel ApelChief Financial Officer09/16/202504/30/202625,000n/a
James HamiltonChief Medical Officer, Head of R&D09/03/202501/16/202672,500n/a
Mauro FerrariBoard Member09/25/202512/31/2025n/a7,530
Patrick O'BrienChief Operating Officer & General Counsel
09/03/202501/07/202677,50020,000
Victoria VakienerBoard Member09/03/202512/31/2025n/a10,040
William WaddillBoard Member09/03/202512/31/2025n/a8,367
(1) This column indicates the total number of shares vesting, but the 10b5-1 Plan provides for the sale of only those shares necessary to satisfy payment of applicable withholding taxes.
Non-Rule 10b5-1 Arrangement Adopted false
Rule 10b5-1 Arrangement Terminated false
Non-Rule 10b5-1 Arrangement Terminated false
Adeoye Olukotun [Member]  
Trading Arrangements, by Individual  
Name Adeoye Olukotun
Title Board Member
Rule 10b5-1 Arrangement Adopted true
Adoption Date 09/04/2025
Expiration Date 12/24/2025
Arrangement Duration 111 days
Aggregate Available 10,000
Christopher Anzalone [Member]  
Trading Arrangements, by Individual  
Name Christopher Anzalone
Title President and Chief Executive Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date 09/19/2025
Expiration Date 12/24/2026
Arrangement Duration 461 days
Aggregate Available 50,000
Daniel Apel [Member]  
Trading Arrangements, by Individual  
Name Daniel Apel
Title Chief Financial Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date 09/16/2025
Expiration Date 04/30/2026
Arrangement Duration 226 days
Aggregate Available 25,000
James Hamilton [Member]  
Trading Arrangements, by Individual  
Name James Hamilton
Title Chief Medical Officer, Head of R&D
Rule 10b5-1 Arrangement Adopted true
Adoption Date 09/03/2025
Expiration Date 01/16/2026
Arrangement Duration 135 days
Aggregate Available 72,500
Mauro Ferrari [Member]  
Trading Arrangements, by Individual  
Name Mauro Ferrari
Title Board Member
Rule 10b5-1 Arrangement Adopted true
Adoption Date 09/25/2025
Expiration Date 12/31/2025
Arrangement Duration 97 days
Aggregate Available 7,530
Patrick O'Brien [Member]  
Trading Arrangements, by Individual  
Name Patrick O'Brien
Title Chief Operating Officer & General Counsel
Rule 10b5-1 Arrangement Adopted true
Adoption Date 09/03/2025
Expiration Date 01/07/2026
Arrangement Duration 126 days
Victoria Vakiener [Member]  
Trading Arrangements, by Individual  
Name Victoria Vakiener
Title Board Member
Rule 10b5-1 Arrangement Adopted true
Adoption Date 09/03/2025
Expiration Date 12/31/2025
Arrangement Duration 119 days
Aggregate Available 10,040
William Waddill [Member]  
Trading Arrangements, by Individual  
Name William Waddill
Title Board Member
Rule 10b5-1 Arrangement Adopted true
Adoption Date 09/03/2025
Expiration Date 12/31/2025
Arrangement Duration 119 days
Aggregate Available 8,367
Patrick O'Brien, Shares Vesting And Subject to Sell-To-Cover [Member] | Patrick O'Brien [Member]  
Trading Arrangements, by Individual  
Aggregate Available 77,500
Patrick O'Brien, Other Shares Being Sold [Member] | Patrick O'Brien [Member]  
Trading Arrangements, by Individual  
Aggregate Available 20,000