Segment Reporting - Schedule of Consolidated Net Income (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Revenues from External Customers and Long-Lived Assets [Line Items]
Total revenues	$ 4,241,217	$ 3,695,649	$ 3,394,635
Costs, expenses and other:
Cost of product revenues (including definite-lived intangible amortization)	312,068	254,990	206,997
Loss on change in fair value of acquisition-related contingent consideration	19,803	29,202	12,149
(Profit) and loss sharing under collaboration agreements	(1,025)	2,045	7,973
Net income	32,615	597,599	340,660
Reportable Segment
Revenues from External Customers and Long-Lived Assets [Line Items]
Total revenues	4,241,217	3,695,649	3,394,635
Costs, expenses and other:
Cost of product revenues (including definite-lived intangible amortization)	312,068	254,990	206,997
Research and development - internal	957,043	815,025	739,785
Research and development - external	866,005	775,919	720,201
Other research and development	783,800	36,650	125,950
Sales and marketing	945,428	876,703	770,141
General and administrative	296,729	284,590	231,999
Loss on change in fair value of acquisition-related contingent consideration	19,803	29,202	12,149
(Profit) and loss sharing under collaboration agreements	(1,025)	2,045	7,973
Other segment items	28,751	22,926	238,780
Net income	32,615	597,599	340,660
Product revenues, net
Revenues from External Customers and Long-Lived Assets [Line Items]
Total revenues	3,618,888	3,165,168	2,746,897
Product revenues, net | Reportable Segment
Revenues from External Customers and Long-Lived Assets [Line Items]
Total revenues	3,618,888	3,165,168	2,746,897
Product royalty revenues
Revenues from External Customers and Long-Lived Assets [Line Items]
Total revenues	579,329	523,481	482,738
Product royalty revenues | Reportable Segment
Revenues from External Customers and Long-Lived Assets [Line Items]
Total revenues	579,329	523,481	482,738
Milestone and contract revenues
Revenues from External Customers and Long-Lived Assets [Line Items]
Total revenues	43,000	7,000	165,000
Milestone and contract revenues | Reportable Segment
Revenues from External Customers and Long-Lived Assets [Line Items]
Total revenues	$ 43,000	$ 7,000	$ 165,000