Commitments and contingencies - Contingencies (Details) - U.S. Centers for Medicare and Medicaid Services - JAKAFI $ in Millions	12 Months Ended
	Dec. 31, 2024 USD ($)
Contingencies
Loss contingences, gross to net deduction percentage (as percent)	6.30%
Accrued and Other Current Liabilities
Contingencies
Loss contingency accrual	$ 127.6