Income Taxes - Schedule of Reconciliation of Income Taxes (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Reconciliation of income taxes at the U.S. federal statutory rate to the provision for income taxes
Provision at U.S. federal statutory rate	$ 66,492	$ 175,185	$ 111,114
State and local income taxes	51,753	21,145	26,767
Foreign tax rate differential	61,026	(96,434)	13,670
Income tax credits	(70,989)	(1,433,507)	(30,505)
Change in valuation allowance	21,425	1,572,951	67,056
Change in uncertain tax positions	6,418	5,943	3,262
Foreign-derived intangible income	(31,786)	(32,891)	(36,748)
Stock based compensation	25,647	20,971	19,704
Acquisitions accounted for as research and development expenses	149,287	4,200	14,700
Other	4,742	(947)	(564)
Total provision for income taxes	284,015	236,616	$ 188,456
Deferred tax assets:
Net operating loss carry forwards	315,969	326,446
Income tax credits	1,398,495	1,441,981
Capitalized research and development	648,989	457,603
Deferred revenue and accruals	190,446	130,291
Non-cash compensation	100,788	96,469
Acquisition-related contingent consideration	27,796	30,298
Intangibles, net	229,741	233,311
Long term investments	6,697	42,975
Other	20,814	9,044
Total gross deferred tax assets	2,939,735	2,768,418
Less valuation allowance for deferred tax assets	(2,139,673)	(2,096,318)
Net deferred tax assets	800,062	672,100
Deferred tax liabilities:
Property and equipment	(30,676)	(34,757)
Other	(7,315)	(5,457)
Total gross deferred tax liabilities	(37,991)	(40,214)
Net deferred tax assets	$ 762,071	$ 631,886