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License Agreements - Syndax (Details) - USD ($) $ in Thousands	1 Months Ended		12 Months Ended			40 Months Ended
	Aug. 31, 2024	Sep. 30, 2021	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2024
License agreements
Long term equity investments			$ 18,814	$ 187,716		$ 18,814
Research and development			$ 2,606,848	1,627,594	$ 1,585,936
Investment in Syndax
License agreements
Investment owned (in shares)			1,400,000			1,400,000
Long term equity investments			$ 18,800	30,700		$ 18,800
Realized and unrealized gain (loss) on equity investments			(11,900)	(5,500)	$ 5,100
Syndax
License agreements
Upfront payment under license agreement						129,500
Research and development			18,800	25,800
Accrued and other liabilities			2,200	$ 1,800		2,200
Syndax \| Regulatory Milestone
License agreements
Milestone payment made under license agreement	$ 12,500
Milestone payment, estimated useful life	10 years
Syndax \| Development and Regulatory Milestones \| Maximum
License agreements
Additional milestone payments under the license agreement			207,500			207,500
Syndax \| Commercialization Milestones \| Maximum
License agreements
Additional milestone payments under the license agreement			$ 230,000			$ 230,000
Syndax \| Incyte
License agreements
Funding of future development costs			55.00%	55.00%
Syndax \| United States \| Syndax
License agreements
Funding of future development costs		45.00%
Syndax \| United States \| Incyte
License agreements
Funding of future development costs		55.00%