CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Revenues:
Total revenues	$ 4,241,217	$ 3,695,649	$ 3,394,635
Costs, expenses and other:
Cost of product revenues (including definite-lived intangible amortization)	312,068	254,990	206,997
Research and development	2,606,848	1,627,594	1,585,936
Selling, general and administrative	1,242,157	1,161,293	1,002,140
Loss on change in fair value of acquisition-related contingent consideration	19,803	29,202	12,149
(Profit) and loss sharing under collaboration agreements	(1,025)	2,045	7,973
Total costs, expenses and other	4,179,851	3,075,124	2,815,195
Income from operations	61,366	620,525	579,440
Interest income	128,710	158,414	40,451
Interest expense	(2,280)	(2,551)	(2,666)
Realized and unrealized gain (loss) on equity investments	116,025	43,893	(87,590)
Interest income	12,809	13,934	(519)
Income before provision for income taxes	316,630	834,215	529,116
Provision for income taxes	284,015	236,616	188,456
Net income	$ 32,615	$ 597,599	$ 340,660
Net income per share:
Basic (in dollars per share)	$ 0.16	$ 2.67	$ 1.53
Diluted (in dollars per share)	$ 0.15	$ 2.65	$ 1.52
Shares used in computing net income per share:
Basic (in shares)	207,110	223,628	222,004
Diluted (in shares)	210,530	225,928	223,958
Product revenues, net
Revenues:
Total revenues	$ 3,618,888	$ 3,165,168	$ 2,746,897
Product royalty revenues
Revenues:
Total revenues	579,329	523,481	482,738
Milestone and contract revenues
Revenues:
Total revenues	$ 43,000	$ 7,000	$ 165,000