Stockholders' Equity (Tables)

12 Months Ended

Dec. 31, 2024

Stockholders' Equity Note [Abstract]

Schedule of Option Activity Under the 2010 Stock Plan

Option activity under the 2010 Stock Plan and 2024 Inducement Plan was as follows:

	Shares Subject to Outstanding Options
	Shares	Weighted Average Exercise Price
Balance at December 31, 2023	12,457,158	$	85.40
Options granted	1,336,397	$	62.58
Options exercised	(430,563)	$	68.69
Options cancelled	(585,018)	$	88.22
Balance at December 31, 2024	12,777,974	$	83.45

Schedule of Stock Options Outstanding and Exercisable by Exercise Price Range

The following table summarizes information about stock options outstanding as of December 31, 2024 under the 2010 Stock Plan and 2024 Inducement Plan:

	Options Outstanding				Options Exercisable
Range of Exercise Prices	Number Outstanding	Weighted Average Remaining Contractual Life (in years)	Weighted Average Exercise Price		Number Exercisable	Weighted Average Exercise Price
$52.94 - $61.76	1,443,974	8.50	$	60.81	533,680	$	61.16
$62.08 - $68.62	1,373,343	6.85	66.21		674,083	68.19
$68.70 - $74.78	1,971,358	5.41	73.13		1,791,120	73.10
$74.98 - $80.50	1,517,319	5.84	78.55		1,235,573	78.82
$80.56 - $83.58	1,449,127	6.69	83.26		1,163,248	83.27
$83.83 - $90.00	1,301,907	3.70	84.80		1,264,003	84.79
$90.56 - $95.34	1,354,618	4.55	92.79		1,353,093	92.79
$95.54 - $113.64	1,780,144	3.30	107.78		1,780,144	107.78
$115.19 - $134.38	568,742	2.39	128.65		568,742	128.65
$138.52 - $138.52	17,442	2.25	138.52		17,442	138.52
	12,777,974				10,381,128

Schedule of Activity Summarized Under all Stock Plans other than Options

RSU and PSU award activity under the 2010 Stock Plan and 2024 Inducement Plan was as follows:

	Shares Subject to Outstanding Awards
	Shares	Grant Date Value
Balance at December 31, 2023	7,165,342	$	72.17
RSUs granted	3,481,911	$	63.97
PSUs granted	341,943	$	65.40
RSUs released	(1,899,523)	$	75.55
PSUs released	(105,453)	$	83.58
RSUs cancelled	(317,347)	$	69.60
PSUs cancelled	(10,070)	$	76.59
Balance at December 31, 2024	8,656,803	$	67.81

Schedule of Share Activity

The following table summarizes our shares available for grant under the 2010 Plan and 2024 Inducement Plan. Each RSU and PSU grant reduces the available share pool by 2 shares.

	Shares Available for Grant
Balance at December 31, 2023	10,815,026
Additional authorization - 2024 Inducement Plan	1,000,000
Options, RSUs and PSUs granted and issuance of shares for services rendered	(9,033,557)
Options, RSUs and PSUs cancelled	1,232,142
Balance at December 31, 2024	4,013,611