CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities:
Net income	$ 199,424	$ 202,991
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization	32,945	28,295
Stock-based compensation	90,337	92,090
Deferred income taxes	32,475	(160)
Other, net	8,467	3,214
Unrealized loss on long term investments	71,482	944
Change in fair value of acquisition-related contingent consideration	9,695	10,158
Changes in operating assets and liabilities:
Accounts receivable	(66,668)	43,824
Prepaid expenses and other assets	(25,380)	(2,981)
Inventory	(37,190)	(16,287)
Accounts payable	22,660	23,333
Accrued and other liabilities	51,651	(6,382)
Net cash provided by operating activities	389,898	379,039
Cash flows from investing activities:
Purchase of long term investments		(8,662)
Sale of long term investments		9,328
Capital expenditures	(28,749)	(114,390)
Purchases of marketable securities	(43,988)	(102,288)
Sale and maturities of marketable securities	43,509	107,114
Net cash used in investing activities	(29,228)	(108,898)
Cash flows from financing activities:
Proceeds from issuance of common stock under stock plans	37,692	43,669
Tax withholdings related to restricted and performance share vesting	(6,854)	(12,625)
Payment of finance lease liabilities	(1,368)	(1,173)
Payment of contingent consideration	(13,473)	(13,357)
Net cash provided by financing activities	15,997	16,514
Effect of exchange rates on cash, cash equivalents, restricted cash and investments	1,198	(2,159)
Net increase in cash, cash equivalents, restricted cash and investments	377,865	284,496
Cash, cash equivalents, restricted cash and investments at beginning of period	2,059,160	1,514,765
Cash, cash equivalents, restricted cash and investments at end of period	2,437,025	1,799,261
Supplemental Schedule of Cash Flow Information
Income taxes paid	76,464	35,996
Unpaid purchases of property and equipment	8,952	30,823
Leased assets obtained in exchange for new operating lease liabilities	2,025	7,217
Leased assets obtained in exchange for new finance lease liabilities	$ 1,308	$ 408