Property and Equipment, net - Property and equipment, net (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Property and equipment, net
Property and Equipment, gross	$ 913,186	$ 899,640
Less accumulated depreciation and amortization	(191,858)	(175,720)
Property and Equipment, net	721,328	723,920
Office equipment
Property and equipment, net
Property and Equipment, gross	22,461	22,554
Laboratory equipment
Property and equipment, net
Property and Equipment, gross	110,400	105,040
Computer equipment
Property and equipment, net
Property and Equipment, gross	86,182	79,871
Land
Property and equipment, net
Property and Equipment, gross	10,265	10,494
Building and leasehold improvements
Property and equipment, net
Property and Equipment, gross	433,151	434,321
Operating lease right-of-use assets
Property and equipment, net
Property and Equipment, gross	24,058	27,308
Construction in Progress
Property and equipment, net
Property and Equipment, gross	$ 226,669	$ 220,052

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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