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Represents the percentage of future global development costs funded under the license agreement.

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Represents the potential milestone payments to be made under the license agreement if profit sharing is terminated.

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Represents the percentage of profits (losses).

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Represents the purchase of common stock under Stock Purchase Agreement.

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The percentage of ownership of common stock or equity participation in the investee accounted for under the equity method of accounting.

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Amount of unrealized gain (loss) on investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI).

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Balance held at close of period in number of shares.

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The total amount of investments that are intended to be held for an extended period of time (longer than one operating cycle).

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Price of a single share of a number of saleable stocks of a company.

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Ratio applied to the conversion of stock split, for example but not limited to, one share converted to two or two shares converted to one.

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License Agreements - Calithera (Details) $ / shares in Units, $ in Thousands	1 Months Ended		3 Months Ended		6 Months Ended		66 Months Ended
	Jun. 30, 2022 USD ($) shares	Jan. 31, 2017 USD ($) $ / shares shares	Jun. 30, 2022 USD ($) shares	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($) shares	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($) shares	Dec. 31, 2021 USD ($)
License agreements
Long term investments	$ 149,784		$ 149,784		$ 149,784		$ 149,784	$ 221,266
Research and development expense			347,196	$ 343,511	700,569	$ 650,407
Unrealized gain (loss) on long term investments			(24,897)	26,765	(71,482)	(944)
Calithera
License agreements
Long term investments	$ 200		$ 200		$ 200		$ 200	$ 1,100
Ownership percentage (as a percent)	2.00%		2.00%		2.00%		2.00%
Calithera \| Other Comprehensive Income
License agreements
Unrealized gain (loss) on long term investments			$ (500)	$ (500)	$ (900)	$ (4,800)
Calithera
License agreements
Funding of future development costs (as a percent)		70.00%
Milestone payment made under license agreement							$ 12,000
Calithera \| U.S.
License agreements
Percentage of profit (losses)		60.00%
Calithera \| Development, Regulatory and Commercialization Milestones \| Maximum
License agreements
Potential milestone payments to be made with profit sharing terminated		$ 720,000
Stock purchase agreement \| Calithera
License agreements
Purchase of common stock under Stock Purchase Agreement (in shares ) \| shares		1,700,000
Purchase price of common stock		$ 8,000
Per share price \| $ / shares		$ 4.65
Effected stock split (as a percent)	0.05
Ownership (in shares) \| shares	86,021		86,021		86,021		86,021