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License Agreements - Agenus (Details) - USD ($)
$ / shares in Units, $ in Thousands, shares in Millions
3 Months Ended 6 Months Ended 12 Months Ended 90 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2017
Jun. 30, 2022
License agreements                
Long term investments $ 149,784   $ 149,784   $ 221,266     $ 149,784
Unrealized gain (loss) on long term investments (24,897) $ 26,765 (71,482) $ (944)        
Research and development expense 347,196 343,511 700,569 650,407        
Agenus                
License agreements                
Long term investments $ 23,400   $ 23,400   $ 38,900     $ 23,400
Shares divested (in shares)         2.0 3.7    
Gross proceeds from sale of stock         $ 10,500 $ 17,200    
Ownership percentage (as a percent) 5.00%   5.00%         5.00%
Unrealized gain (loss) on long term investments $ (6,300) $ 37,800 $ (15,400) $ 31,900        
Royalty-bearing product GITR, OX40 and one undisclosed target | Agenus | Maximum                
License agreements                
Royalty payments on future global net sales (as a percent)     15.00%          
Agenus                
License agreements                
Period of notice for termination of license agreement     12 months          
Agenus | Royalty-bearing product other than GITR, OX40 and one undisclosed target | Minimum                
License agreements                
Royalty payments on future global net sales (as a percent)     6.00%          
Agenus | Royalty-bearing product other than GITR, OX40 and one undisclosed target | Maximum                
License agreements                
Royalty payments on future global net sales (as a percent)     12.00%          
Agenus | Development, Regulatory and Commercialization Milestones                
License agreements                
Milestone payment made under license agreement               $ 30,000
Additional milestone payments under the license agreement $ 500,000   $ 500,000         $ 500,000
Stock purchase agreement | Agenus                
License agreements                
Purchase of common stock under Stock Purchase Agreement (in shares )             10.0  
Purchase price of common stock             $ 60,000  
Per share price             $ 6.00