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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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License Agreements - Lilly (Details) - USD ($) $ in Thousands	1 Months Ended				3 Months Ended		6 Months Ended		151 Months Ended
	Jun. 30, 2022	Mar. 31, 2022	May 31, 2019	Dec. 31, 2009	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Mar. 31, 2016
License agreements
Research and Development Expense					$ 347,196	$ 343,511	$ 700,569	$ 650,407
Revenues					911,397	705,709	1,644,632	1,310,427
OLUMIANT Royalty Revenues
License agreements
Revenues					30,254	36,045	78,318	68,303
Eli Lilly \| Development Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone									$ 149,000
Eli Lilly \| Development Milestones \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement				$ 150,000
Eli Lilly \| Regulatory Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone									335,000
Eli Lilly \| Regulatory Milestones \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement				365,000
Eli Lilly \| Commercialization Milestones
License agreements
Amount recognized and received for the achievement of a predefined milestone									$ 50,000
Eli Lilly \| Commercialization Milestones \| Maximum
License agreements
Upfront and immediate milestone payment to be received under license agreement				$ 150,000
Eli Lilly \| OLUMIANT
License agreements
Revenues					70,000		70,000
Eli Lilly \| OLUMIANT \| Regulatory Milestones \| U.S.
License agreements
Amount recognized and received for the achievement of a predefined milestone	$ 40,000
Eli Lilly \| OLUMIANT \| Regulatory Milestones \| Europe
License agreements
Amount recognized and received for the achievement of a predefined milestone	20,000
Eli Lilly \| OLUMIANT \| Regulatory Milestones \| Japan
License agreements
Amount recognized and received for the achievement of a predefined milestone	$ 10,000
Eli Lilly \| OLUMIANT Royalty Revenues \| Non-U.S.
License agreements
Revenues					$ 30,300	$ 36,000	$ 78,300	$ 68,300
Eli Lilly \| GVHD \| Regulatory Milestones
License agreements
Milestone payment made under license agreement			$ 20,000
Eli Lilly \| GVHD \| Regulatory Milestones \| Europe
License agreements
Milestone payment made under license agreement		$ 20,000
Eli Lilly \| GVHD \| Regulatory Milestones \| Maximum
License agreements
Additional milestone payments under the license agreement										$ 40,000