CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenues:
Total revenues	$ 911,397	$ 705,709	$ 1,644,632	$ 1,310,427
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	50,636	38,028	93,250	67,248
Research and development	347,196	343,511	700,569	650,407
Selling, general and administrative	253,277	168,859	462,861	322,654
Change in fair value of acquisition-related contingent consideration	3,313	4,632	9,695	10,158
Collaboration loss sharing	2,544	9,843	7,286	20,327
Total costs and expenses	656,966	564,873	1,273,661	1,070,794
Income from operations	254,431	140,836	370,971	239,633
Other income (expense), net	522	4,390	1,782	2,983
Interest expense	(678)	(358)	(1,358)	(717)
Unrealized (loss) gain on long term investments	(24,897)	26,765	(71,482)	(944)
Income before provision for income taxes	229,378	171,633	299,913	240,955
Provision for income taxes	67,946	22,177	100,489	37,964
Net income	$ 161,432	$ 149,456	$ 199,424	$ 202,991
Net income per share:
Basic	$ 0.73	$ 0.68	$ 0.90	$ 0.92
Diluted	$ 0.72	$ 0.67	$ 0.89	$ 0.91
Shares used in computing net income per share:
Basic	221,660	220,083	221,493	219,942
Diluted	223,661	222,250	223,277	222,061
Product revenues, net
Revenues:
Total revenues	$ 663,851	$ 575,150	$ 1,269,672	$ 1,079,961
Product royalty revenues
Revenues:
Total revenues	117,546	120,559	239,960	220,466
Milestone revenues
Revenues:
Total revenues	$ 130,000	$ 10,000	$ 135,000	$ 10,000