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Fair Value of Financial Instruments - Fair value on a recurring basis (Details)
$ in Thousands
6 Months Ended 12 Months Ended
Jun. 01, 2016
Jun. 30, 2022
USD ($)
Dec. 31, 2021
USD ($)
Fair value of financial instruments      
Long term investments   $ 149,784 $ 221,266
ARIAD | Contingent Consideration      
Roll forward of Level 3 liabilities      
Projected cash flows period 18 years    
ARIAD | Discount rate | Contingent Consideration      
Roll forward of Level 3 liabilities      
Valuation input (as a percent) 10 0.10 0.10
ARIAD | Accrued and other current liabilities      
Roll forward of Level 3 liabilities      
Contingent consideration earned during the period but not yet paid   $ (16,700) $ (19,600)
Level 3 | Estimate of Fair Value Measurement [Member]      
Roll forward of Level 3 liabilities      
Balance at the beginning of the period   244,000  
Contingent consideration earned during the period but not yet paid   (16,695)  
Change in fair value of contingent consideration   9,695  
Balance at the end of the period   237,000 244,000
Fair Value, Measurements, Recurring [Member] | Estimate of Fair Value Measurement [Member]      
Fair value of financial instruments      
Cash and cash equivalents   2,435,381 2,057,440
Debt securities (government)   287,044 290,752
Long term investments   149,784 221,266
Total assets   2,872,209 2,569,458
Acquisition-related contingent consideration   237,000 244,000
Total liabilities   237,000 244,000
Fair Value, Measurements, Recurring [Member] | Fair Value, Inputs, Level 1 [Member]      
Fair value of financial instruments      
Cash and cash equivalents   2,435,381 2,057,440
Long term investments   149,784 221,266
Total assets   2,585,165 2,278,706
Fair Value, Measurements, Recurring [Member] | Fair Value, Inputs, Level 2 [Member]      
Fair value of financial instruments      
Debt securities (government)   287,044 290,752
Total assets   287,044 290,752
Fair Value, Measurements, Recurring [Member] | Level 3      
Fair value of financial instruments      
Acquisition-related contingent consideration   237,000 244,000
Total liabilities   $ 237,000 $ 244,000