CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
Mar. 31, 2022	Mar. 31, 2021
Cash flows from operating activities:
Net income	$ 37,992	$ 53,535
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization	16,438	13,838
Stock-based compensation	43,841	47,358
Deferred income taxes	2,106	70
Other, net	2,091	4,622
Unrealized loss on long term investments	46,585	27,709
Change in fair value of acquisition-related contingent consideration	6,382	5,526
Changes in operating assets and liabilities:
Accounts receivable	53,956	84,637
Prepaid expenses and other assets	(13,971)	(10,777)
Inventory	(13,903)	(4,406)
Accounts payable	(19,563)	(13,709)
Accrued and other liabilities	53,787	(2,308)
Net cash provided by operating activities	215,741	206,095
Cash flows from investing activities:
Purchase of long term investments		(8,662)
Sale of long term investments		1,080
Capital expenditures	(17,006)	(48,083)
Purchases of marketable securities		(39,301)
Sale and maturities of marketable securities	258	35,213
Net cash used in investing activities	(16,748)	(59,753)
Cash flows from financing activities:
Proceeds from issuance of common stock under stock plans	16,398	22,376
Tax withholdings related to restricted and performance share vesting	(2,161)	(2,348)
Payment of finance lease liabilities	(668)	(573)
Payment of contingent consideration	(13,473)	(6,620)
Net cash provided by financing activities	96	12,835
Effect of exchange rates on cash, cash equivalents, restricted cash and investments	210	(2,331)
Net increase in cash, cash equivalents, restricted cash and investments	199,299	156,846
Cash, cash equivalents, restricted cash and investments at beginning of period	2,059,160	1,514,765
Cash, cash equivalents, restricted cash and investments at end of period	2,258,459	1,671,611
Supplemental Schedule of Cash Flow Information
Income taxes paid	3,472	339
Unpaid purchases of property and equipment	15,764	21,262
Leased assets obtained in exchange for new operating lease liabilities	1,618	1,898
Leased assets obtained in exchange for new finance lease liabilities	$ 584	$ 68

The cash outflow with regard to the contingent consideration during the period.

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