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Accrued and Other Current Liabilities (Details) - USD ($)
$ in Thousands
Mar. 31, 2022
Dec. 31, 2021
Accrued and Other Current Liabilities    
Royalties $ 171,957 $ 168,412
Clinical related costs 137,241 109,486
Sales allowances 162,997 136,541
Sales and marketing 37,134 35,750
Construction in progress 15,763 27,098
Operating lease liabilities 9,904 10,554
Other current liabilities 74,294 45,754
Total accrued and other current liabilities $ 609,290 $ 533,595 [1]
[1] The condensed consolidated balance sheet at December 31, 2021 has been derived from the audited consolidated financial statements at that date.