CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Revenues:
Total revenues	$ 733,235	$ 604,718
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	42,614	29,220
Research and development	353,373	306,896
Selling, general and administrative	209,584	153,795
Change in fair value of acquisition-related contingent consideration	6,382	5,526
Collaboration loss sharing	4,742	10,484
Total costs and expenses	616,695	505,921
Income from operations	116,540	98,797
Other income (expense), net	1,260	(1,407)
Interest expense	(680)	(359)
Unrealized loss on long term investments	(46,585)	(27,709)
Income before provision for income taxes	70,535	69,322
Provision for income taxes	32,543	15,787
Net income	$ 37,992	$ 53,535
Net income per share:
Basic	$ 0.17	$ 0.24
Diluted	$ 0.17	$ 0.24
Shares used in computing net income per share:
Basic	221,326	219,801
Diluted	222,950	221,867
Product revenues, net
Revenues:
Total revenues	$ 605,821	$ 504,811
Product royalty revenues
Revenues:
Total revenues	122,414	$ 99,907
Milestone and contract revenues
Revenues:
Total revenues	$ 5,000