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Accrued and Other Current Liabilities (Tables)
3 Months Ended
Mar. 31, 2022
Accrued and Other Current Liabilities  
Schedule of accrued and other current liabilities

Accrued and other current liabilities consisted of the following (in thousands):

March 31,

December 31,

    

2022

    

2021

Royalties

    

$

171,957

$

168,412

Clinical related costs

137,241

    

 

109,486

Sales allowances

162,997

136,541

Sales and marketing

37,134

35,750

Construction in progress

15,763

27,098

Operating lease liabilities

9,904

10,554

Other current liabilities

 

74,294

 

45,754

Total accrued and other current liabilities

$

609,290

$

533,595