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Stock Compensation (Details) - USD ($)
$ / shares in Units, $ in Millions
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Stock compensation      
Stock compensation expense $ 183.0 $ 177.9 $ 166.6
Stock Compensation Expense Capitalized $ 2.1 0.6 0.4
Weighted-average fair value assumptions      
Valuation method Black-Scholes valuation model    
Dividend yield (as a percent) 0.00%    
Research and Development Expense [Member]      
Stock compensation      
Stock compensation expense $ 114.3 120.4 114.0
Selling, General and Administrative Expenses [Member]      
Stock compensation      
Stock compensation expense 67.0 56.6 51.9
Cost of product revenues      
Stock compensation      
Stock compensation expense 1.7 1.0 0.7
Employee Stock [Member]      
Stock compensation      
Stock compensation expense $ 4.6 $ 4.6 $ 3.4
Weighted-average fair value assumptions      
Average risk-free interest rates (as a percent) 0.40% 0.17% 1.82%
Average expected life (in years) 6 months 6 months 6 months
Volatility (as a percent) 33.00% 45.00% 31.00%
Weighted-average fair value (in dollars per share) $ 18.02 $ 19.13 $ 14.04
Employee Stock Option      
Stock compensation      
Assumed annualized forfeiture rate (as a percent) 5.00%    
Weighted-average fair value assumptions      
Average risk-free interest rates (as a percent) 0.62% 0.80% 2.27%
Average expected life (in years) 5 years 3 days 4 years 11 months 23 days 5 years 3 months 7 days
Volatility (as a percent) 39.00% 40.00% 45.00%
Weighted-average fair value (in dollars per share) $ 29.03 $ 32.65 $ 32.38
Unrecognized compensation      
Unrecognized compensation cost for nonvested option (in dollars) $ 62.2    
Vesting period of recognition of the unrecognized compensation cost of nonvested awards 1 year 1 month 6 days    
Restricted Stock Units (RSUs) [Member]      
Stock compensation      
Assumed annualized forfeiture rate (as a percent) 5.00%    
Unrecognized compensation      
Unrecognized compensation cost for nonvested option (in dollars) $ 162.9    
Vesting period of recognition of the unrecognized compensation cost of nonvested awards 1 year 10 months 24 days    
Performance Stock Units (PSUs)      
Stock compensation      
Stock compensation expense $ 8.3 $ 13.9 $ 9.9
Assumed annualized forfeiture rate (as a percent) 5.00%    
Unrecognized compensation      
Unrecognized compensation cost for nonvested option (in dollars) $ 24.3    
Vesting period of recognition of the unrecognized compensation cost of nonvested awards 1 year 10 months 24 days