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License Agreements - Lilly (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended 145 Months Ended
May 31, 2019
Dec. 31, 2009
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2021
Mar. 31, 2016
License agreements              
Research and Development Expense     $ 1,458,179 $ 2,215,942 $ 1,154,111    
Revenues     2,986,267 2,666,702 2,158,759    
Europe              
License agreements              
Revenues     124,100 105,000 90,000    
Product royalty revenues              
License agreements              
Revenues     569,255 392,966 306,337    
Eli Lilly              
License agreements              
Revenues     50,000 30,000 0    
Eli Lilly | Non-U.S.              
License agreements              
Revenues     220,900 $ 110,900 $ 80,400    
Eli Lilly | Development Milestones              
License agreements              
Amount recognized and received for the achievement of a predefined milestone           $ 149,000  
Eli Lilly | Development Milestones | Maximum              
License agreements              
Upfront and immediate milestone payment to be received under license agreement   $ 150,000          
Eli Lilly | Regulatory Milestones              
License agreements              
Amount recognized and received for the achievement of a predefined milestone           265,000  
Eli Lilly | Regulatory Milestones | Japan              
License agreements              
Amount recognized and received for the achievement of a predefined milestone     10,000        
Eli Lilly | Regulatory Milestones | Europe              
License agreements              
Amount recognized and received for the achievement of a predefined milestone     20,000        
Eli Lilly | Regulatory Milestones | Maximum              
License agreements              
Upfront and immediate milestone payment to be received under license agreement   365,000          
Eli Lilly | Commercialization Milestones              
License agreements              
Amount recognized and received for the achievement of a predefined milestone     50,000     $ 50,000  
Annual net sales of a licensed product for the achievement of a predefined milestone     $ 1,000,000        
Eli Lilly | Commercialization Milestones | Maximum              
License agreements              
Upfront and immediate milestone payment to be received under license agreement   $ 150,000          
Eli Lilly | GVHD              
License agreements              
Additional milestone payments under the license agreement             $ 40,000
Eli Lilly | GVHD | Regulatory Milestones              
License agreements              
Milestone payment made under license agreement $ 20,000