Inventory (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Inventory
Raw materials	$ 1,275	$ 1,275
Work-in-process	39,895	21,242
Finished goods	15,768	13,456
Total inventories	56,938	35,973
Inventories - current	27,904	16,425
Inventories-noncurrent	29,034	$ 19,548
Inventory incurred prior to FDA approval	$ 71,900
Period of lower average per unit cost of materials	36 months