CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues:
Total revenues	$ 2,986,267	$ 2,666,702	$ 2,158,759
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	150,991	131,328	114,249
Research and development	1,458,179	2,215,942	1,154,111
Selling, general and administrative	739,560	516,922	468,711
Change in fair value of acquisition-related contingent consideration	14,741	23,385	19,682
Collaboration loss sharing	37,019	42,801
Total costs and expenses	2,400,490	2,930,378	1,756,753
Income (loss) from operations	585,777	(263,676)	402,006
Other income (expense), net	10,647	23,206	52,182
Interest expense	(1,908)	(2,174)	(1,855)
Unrealized (loss) gain on long term investments	(24,072)	10,426	34,458
Income (loss) before (benefit) provision for income taxes	570,444	(232,218)	486,791
(Benefit) provision for income taxes	(378,137)	63,479	39,885
Net income (loss)	$ 948,581	$ (295,697)	$ 446,906
Net income (loss) per share:
Basic	$ 4.30	$ (1.36)	$ 2.08
Diluted	$ 4.27	$ (1.36)	$ 2.05
Shares used in computing net income (loss) per share:
Basic	220,428	218,073	214,913
Diluted	222,074	218,073	217,657
Product revenues, net
Revenues:
Total revenues	$ 2,322,012	$ 2,068,736	$ 1,774,922
Product royalty revenues
Revenues:
Total revenues	569,255	392,966	306,337
Milestone and contract revenues
Revenues:
Total revenues	$ 95,000	$ 205,000	$ 77,500