CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020
Revenues:
Total revenues	$ 604,718	$ 568,507
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	29,220	27,319
Research and development	306,896	1,085,287
Selling, general and administrative	153,795	111,148
Change in fair value of acquisition-related contingent consideration	5,526	6,627
Collaboration loss sharing	10,484	2,130
Total costs and expenses	505,921	1,232,511
Income (loss) from operations	98,797	(664,004)
Other income (expense), net	(1,407)	8,662
Interest expense	(359)	(602)
Unrealized loss on long term investments	(27,709)	(48,132)
Income (loss) before provision for income taxes	69,322	(704,076)
Provision for income taxes	15,787	16,566
Net income (loss)	$ 53,535	$ (720,642)
Net income (loss) per share:
Basic	$ 0.24	$ (3.33)
Diluted	$ 0.24	$ (3.33)
Shares used in computing net income (loss) per share:
Basic	219,801	216,721
Diluted	221,867	216,721
Product revenues, net
Revenues:
Total revenues	$ 504,811	$ 486,727
Product royalty revenues
Revenues:
Total revenues	$ 99,907	$ 81,780