Interim Consolidated Financial Information (Unaudited) - Narrative (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2020	Sep. 30, 2020	Jun. 30, 2020	Mar. 31, 2020	Dec. 31, 2019	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Interim Consolidated Financial Information (Unaudited)
Revenues	$ 789,509	$ 620,643	$ 688,043	$ 568,507	$ 579,389	$ 551,581	$ 529,932	$ 497,857	$ 2,666,702	$ 2,158,759	$ 1,881,883
Product revenues, net
Interim Consolidated Financial Information (Unaudited)
Revenues	559,500	522,300	500,300	486,700	490,800	454,000	433,900	396,200	2,068,736	1,774,922	1,466,900
Product royalty revenues
Interim Consolidated Financial Information (Unaudited)
Revenues	119,900	98,400	92,800	81,800	88,600	80,100	76,000	61,600	392,966	306,337	234,780
Milestone and contract revenues
Interim Consolidated Financial Information (Unaudited)
Revenues	$ 110,000	$ 0	$ 95,000	$ 0	$ 0	$ 17,500	$ 20,000	$ 40,000	$ 205,000	$ 77,500	$ 180,000