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Fair Value of Financial Instruments - Fair value on a recurring basis (Details)
$ in Thousands
12 Months Ended
Jun. 01, 2016
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Fair value of financial instruments      
Long term investments (Note 6)   $ 222,301 $ 133,657
ARIAD | Contingent Consideration      
Roll forward of Level 3 liabilities      
Projected cash flows period 18 years    
ARIAD | Discount rate | Contingent Consideration      
Roll forward of Level 3 liabilities      
Valuation input (as a percent) 0.10    
ARIAD | Average Cost of Capital | Contingent Consideration      
Roll forward of Level 3 liabilities      
Valuation input (as a percent)   0.10  
ARIAD | Accrued and other current liabilities      
Roll forward of Level 3 liabilities      
Contingent consideration earned during the period but not yet paid   $ 9,600 23,000
Level 3 | Fair Value      
Roll forward of Level 3 liabilities      
Balance at the beginning of the period   277,000 287,001
Contingent consideration earned during the period but not yet paid   (9,595) (23,012)
Payments made during the period   (24,790) (6,671)
Change in fair value of contingent consideration   23,385 19,682
Balance at the end of the period   266,000 277,000
Recurring | Fair Value      
Fair value of financial instruments      
Cash and cash equivalents   1,513,008 1,832,684
Debt securities (government)   288,369 284,870
Long term investments (Note 6)   222,301 133,657
Total assets   2,023,678 2,251,211
Acquisition-related contingent consideration   266,000 277,000
Total liabilities   266,000 277,000
Recurring | Level 1      
Fair value of financial instruments      
Cash and cash equivalents   1,513,008 1,832,684
Long term investments (Note 6)   222,301 133,657
Total assets   1,735,309 1,966,341
Recurring | Level 2      
Fair value of financial instruments      
Debt securities (government)   288,369 284,870
Total assets   288,369 284,870
Recurring | Level 3      
Fair value of financial instruments      
Acquisition-related contingent consideration   266,000 277,000
Total liabilities   $ 266,000 $ 277,000