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License agreements - MacroGenics (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Nov. 30, 2018
Sep. 30, 2018
Dec. 31, 2017
Jun. 30, 2020
Jun. 30, 2019
Jun. 30, 2020
Jun. 30, 2019
Dec. 31, 2019
License agreements                
Research and development       $ 286,601 $ 289,363 $ 1,371,888 $ 559,908  
MacroGenics                
License agreements                
Upfront payment under license agreement     $ 150,000          
Research and development $ 5,000 $ 10,000   16,300 $ 9,800 32,700 $ 19,200  
MacroGenics | Accrued and other liabilities                
License agreements                
Accrued and other liabilities       $ 500   $ 500   $ 1,000
Minimum                
License agreements                
Royalty payments on future global net sales (as a percent)     15.00%          
Maximum | MacroGenics                
License agreements                
Royalty payments on future global net sales (as a percent)     24.00%          
Development and Regulatory Milestones | Maximum | MacroGenics                
License agreements                
Additional milestone payments under the license agreement     $ 420,000          
Sales and Commercial Milestones | Maximum | MacroGenics                
License agreements                
Additional milestone payments under the license agreement     $ 330,000