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License agreements - Merus (Details)
$ / shares in Units, $ in Thousands, € in Millions, shares in Millions
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Jan. 23, 2017
USD ($)
$ / shares
Dec. 31, 2017
Feb. 28, 2017
USD ($)
Jan. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
$ / shares
shares
Jun. 30, 2020
USD ($)
Mar. 31, 2020
EUR (€)
Jun. 30, 2019
USD ($)
Jun. 30, 2020
USD ($)
Jun. 30, 2019
USD ($)
Dec. 31, 2017
USD ($)
Dec. 31, 2019
USD ($)
License agreements                        
Long term investments           $ 248,731     $ 248,731     $ 133,657
Research and development expense           286,601   $ 289,363 1,371,888 $ 559,908    
Unrealized gain (loss) on long term investments           72,274   (4,625) 24,142 16,364    
Current assets           2,077,625     2,077,625     2,481,488
Current liabilities           556,513     556,513     513,340
Minimum                        
License agreements                        
Royalty payments on future global net sales (as a percent)   15.00%                    
Merus                        
License agreements                        
Associated future global development costs , if elected to co-develop (as a percent)       35.00%                
Upfront payment under license agreement     $ 120,000                  
Research and development expense           1,900   1,700 4,200 4,300    
Merus | Accrued and other liabilities                        
License agreements                        
Accrued and other liabilities           2,000     2,000     1,600
Merus | U.S.                        
License agreements                        
Profit sharing (as a percent)       50.00%                
Percentage of profit (losses)       50.00%                
Merus | Minimum                        
License agreements                        
Royalty payments on future global net sales (as a percent)       6.00%                
Merus | Minimum | U.S.                        
License agreements                        
Royalty payments on future global net sales (as a percent)       6.00%                
Merus | Minimum | Non-U.S.                        
License agreements                        
Royalty payments on future global net sales (as a percent)       6.00%                
Merus | Maximum                        
License agreements                        
Royalty payments on future global net sales (as a percent)       10.00%                
Percentage of reverse royalty       4.00%                
Merus | Maximum | U.S.                        
License agreements                        
Royalty payments on future global net sales (as a percent)       10.00%                
Percentage of additional royalties       4.00%                
Merus | Maximum | Non-U.S.                        
License agreements                        
Royalty payments on future global net sales (as a percent)       10.00%                
Merus | Maximum | Development and Regulatory Milestones                        
License agreements                        
Additional milestone payments under the license agreement       $ 100,000                
Merus | Maximum | Sales and Commercial Milestones                        
License agreements                        
Additional milestone payments under the license agreement       $ 250,000                
Merus                        
License agreements                        
Per share price of common stock | $ / shares $ 24.50                      
Discount for lack of marketability $ 5,600                      
Fair value of shares on the issuance date 72,800                      
Total consideration paid 80,000                      
Long term investments $ 72,800                      
Research and development expense                     $ 7,200  
Fair market value of our long term investments           $ 51,500     $ 51,500     $ 45,100
Ownership percentage (as a percent)           11.00%     11.00%      
Unrealized gain (loss) on long term investments           $ 12,700   $ (400) $ 6,400 $ 2,100    
Total revenues | €             € 6.3          
Net loss | €             € (16.5)          
Merus | Stock purchase agreement                        
License agreements                        
Purchase of common stock under Stock Purchase Agreement (in shares ) | shares         3.2              
Purchase price of common stock         $ 80,000              
Per share price | $ / shares         $ 25.00