CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
Revenues:
Total revenues	$ 688,043	$ 529,932	$ 1,256,550	$ 1,027,789
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	33,364	29,406	60,683	51,994
Research and development	286,601	289,363	1,371,888	559,908
Selling, general and administrative	117,998	105,943	229,146	229,926
Change in fair value of acquisition-related contingent consideration	6,054	6,608	12,681	13,279
Collaboration loss sharing	13,253		15,383
Total costs and expenses	457,270	431,320	1,689,781	855,107
Income (loss) from operations	230,773	98,612	(433,231)	172,682
Other income (expense), net	4,817	15,000	13,479	24,373
Interest expense	(600)	(316)	(1,202)	(651)
Unrealized gain (loss) on long term investments	72,274	(4,625)	24,142	16,364
Income (loss) before provision for income taxes	307,264	108,671	(396,812)	212,768
Provision for income taxes	16,966	3,353	33,532	5,138
Net (loss) income	$ 290,298	$ 105,318	$ (430,344)	$ 207,630
Net income (loss) per share:
Basic	$ 1.33	$ 0.49	$ (1.98)	$ 0.97
Diluted	$ 1.32	$ 0.48	$ (1.98)	$ 0.96
Shares used in computing net income (loss) per share:
Basic	217,549	214,620	217,135	214,342
Diluted	220,434	217,483	217,135	217,274
Product revenues, net
Revenues:
Total revenues	$ 500,290	$ 433,897	$ 987,017	$ 830,146
Product royalty revenues
Revenues:
Total revenues	92,753	76,035	174,533	137,643
Milestone revenues
Revenues:
Total revenues	$ 95,000	$ 20,000	$ 95,000	$ 60,000