Accrued and other current liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2020	Dec. 31, 2019
Accrued and Other Current Liabilities
Royalties	$ 73,045	$ 73,221
Clinical related costs	77,913	88,710
Sales allowances	96,062	59,924
Construction in progress	13,582	12,732
Operating lease liabilities	9,021	9,343
Other current liabilities	60,411	42,020
Total accrued and other current liabilities	$ 330,034	$ 285,950	[1]

[1] The condensed consolidated balance sheet at December 31, 2019 has been derived from the audited consolidated financial statements at that date.