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Stock compensation (Details) - USD ($)
$ / shares in Units, $ in Millions
3 Months Ended
Mar. 31, 2020
Mar. 31, 2019
Stock compensation    
Stock compensation expense $ 42.5 $ 40.6
Stock Compensation Expense Capitalized $ 0.2 0.1
Assumed annualized forfeiture rate (as a percent) 5.00%  
Weighted-average fair value assumptions    
Valuation method Black-Scholes valuation model  
Dividend yield (as a percent) 0.00%  
Research and Development Expense    
Stock compensation    
Stock compensation expense $ 28.7 27.4
Selling, General and Administrative Expenses    
Stock compensation    
Stock compensation expense 13.6 13.0
Cost of product revenues    
Stock compensation    
Stock compensation expense $ 0.2 $ 0.2
Employee Stock    
Weighted-average fair value assumptions    
Average risk-free interest rates (as a percent) 0.23% 2.27%
Average expected life (in years) 3 months 3 months
Volatility (as a percent) 52.00% 34.00%
Weighted-average fair value (in dollars per share) $ 16.00 $ 13.31
Stock Options    
Weighted-average fair value assumptions    
Average risk-free interest rates (as a percent) 1.56% 2.51%
Average expected life (in years) 4 years 7 months 24 days 5 years 3 months 29 days
Volatility (as a percent) 40.00% 45.00%
Weighted-average fair value (in dollars per share) $ 28.43 $ 31.50
Unrecognized compensation    
Unrecognized compensation cost for nonvested option (in dollars) $ 95.8  
Vesting period of recognition of the unrecognized compensation cost of nonvested awards 1 year 4 months 24 days  
Restricted Stock Units (RSUs)    
Unrecognized compensation    
Unrecognized compensation cost for nonvested option (in dollars) $ 93.3  
Vesting period of recognition of the unrecognized compensation cost of nonvested awards 1 year 9 months 18 days  
Performance Stock Units (PSUs)    
Unrecognized compensation    
Unrecognized compensation cost for nonvested option (in dollars) $ 29.5  
Vesting period of recognition of the unrecognized compensation cost of nonvested awards 1 year 9 months 18 days