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License agreements - MacroGenics (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended
Nov. 30, 2018
Sep. 30, 2018
Dec. 31, 2017
Mar. 31, 2020
Mar. 31, 2019
Dec. 31, 2019
License agreements            
Research and development       $ 1,085,287 $ 270,545  
MacroGenics            
License agreements            
Upfront payment under license agreement     $ 150,000      
Research and development $ 5,000 $ 10,000   16,400 $ 9,400  
MacroGenics | Accrued and other liabilities            
License agreements            
Accrued and other liabilities       $ 1,600   $ 1,000
Minimum | MacroGenics            
License agreements            
Royalty payments on future global net sales (as a percent)     15.00%      
Maximum | MacroGenics            
License agreements            
Royalty payments on future global net sales (as a percent)     24.00%      
Development and Regulatory Milestones | Maximum | MacroGenics            
License agreements            
Additional milestone payments under the license agreement     $ 420,000      
Commercialization Milestones | Maximum | MacroGenics            
License agreements            
Additional milestone payments under the license agreement     $ 30,000