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License agreements - Lilly (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended 124 Months Ended
May 31, 2019
Mar. 31, 2016
Jul. 31, 2010
Dec. 31, 2009
Mar. 31, 2020
Mar. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Mar. 31, 2020
Dec. 31, 2019
License agreements                    
Research and Development Expense         $ 1,085,287 $ 270,545        
Revenues         568,507 497,857        
Eli Lilly                    
License agreements                    
Upfront payment received under license agreement       $ 90,000            
Product royalties in accounts receivable         $ 25,400       $ 25,400 $ 23,600
Eli Lilly | Phase IIB                    
License agreements                    
Associated future global development costs from the initiation of a Phase IIb trial, if elected to co-develop (as a percentage)     30.00%   30.00%          
Eli Lilly | Pre-specified Events | Maximum                    
License agreements                    
Upfront and immediate milestone payment to be received under license agreement       665,000            
Eli Lilly | Development Milestones                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone             $ 20,000 $ 30,000 149,000  
Eli Lilly | Development Milestones | Maximum                    
License agreements                    
Upfront and immediate milestone payment to be received under license agreement       150,000            
Eli Lilly | Regulatory Milestones                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone             $ 100,000   $ 235,000  
Eli Lilly | Regulatory Milestones | JAPAN                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone               15,000    
Eli Lilly | Regulatory Milestones | Europe                    
License agreements                    
Amount recognized and received for the achievement of a predefined milestone               $ 65,000    
Eli Lilly | Regulatory Milestones | Maximum                    
License agreements                    
Upfront and immediate milestone payment to be received under license agreement       365,000            
Eli Lilly | Commercialization Milestones                    
License agreements                    
Revenues         $ 25,400 16,000        
Eli Lilly | Commercialization Milestones | Maximum                    
License agreements                    
Upfront and immediate milestone payment to be received under license agreement       $ 150,000            
Royalty payments on future global net sales (as a percent)         20.00%          
Eli Lilly | Development and Commercialization Milestones                    
License agreements                    
Revenues         $ 0 $ 0        
Eli Lilly | GVHD                    
License agreements                    
Upfront payment under license agreement   $ 35,000                
Additional milestone payments under the license agreement   $ 40,000                
Eli Lilly | GVHD | Regulatory Milestones                    
License agreements                    
Milestone payment made under license agreement $ 20,000