CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Revenues:
Total revenues	$ 529,932	$ 521,516	$ 1,027,789	$ 903,798
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	29,406	24,856	51,994	42,962
Research and development	289,363	298,089	559,908	601,192
Selling, general and administrative	105,943	108,029	229,926	229,527
Change in fair value of acquisition-related contingent consideration	6,608	7,303	13,279	13,988
Total costs and expenses	431,320	438,277	855,107	887,669
Income from operations	98,612	83,239	172,682	16,129
Other income (expense), net	15,000	5,808	24,373	10,270
Interest expense	(316)	(398)	(651)	(783)
Unrealized gain (loss) on long term investments	(4,625)	(34,641)	16,364	(11,962)
Income before provision for income taxes	108,671	54,008	212,768	13,654
Provision for income taxes	3,353	1,614	5,138	2,400
Net income	$ 105,318	$ 52,394	$ 207,630	$ 11,254
Net income per share:
Basic	$ 0.49	$ 0.25	$ 0.97	$ 0.05
Diluted	$ 0.48	$ 0.24	$ 0.96	$ 0.05
Shares used in computing net income (loss) per share:
Basic	214,620	212,210	214,342	211,945
Diluted	217,483	215,103	217,274	215,294
Product revenues, net
Revenues:
Total revenues	$ 433,897	$ 365,524	$ 830,146	$ 700,029
Product royalty revenues
Revenues:
Total revenues	76,035	55,953	137,643	103,669
Other revenues
Revenues:
Total revenues		39		100
Milestone revenues
Revenues:
Total revenues	$ 20,000	$ 100,000	$ 60,000	$ 100,000