CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Revenues:
Total revenues	$ 497,857	$ 382,282
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	22,588	18,106
Research and development	270,545	303,103
Selling, general and administrative	123,983	121,498
Change in fair value of contingent consideration	6,671	6,685
Total costs and expenses	423,787	449,392
Income (loss) from operations	74,070	(67,110)
Other income (expense), net	9,373	4,462
Interest expense	(335)	(385)
Unrealized gain on long term investments	20,989	22,679
Income (loss) before provision for income taxes	104,097	(40,354)
Provision for income taxes	1,785	786
Net income (loss)	$ 102,312	$ (41,140)
Net income (loss) per share:
Basic	$ 0.48	$ (0.19)
Diluted	$ 0.47	$ (0.19)
Shares used in computing net income (loss) per share:
Basic	214,065	211,681
Diluted	217,061	211,681
Product revenues, net
Revenues:
Total revenues	$ 396,249	$ 334,505
Product royalty revenues
Revenues:
Total revenues	61,608	47,716
Other revenues
Revenues:
Total revenues		$ 61
Milestone revenues
Revenues:
Total revenues	$ 40,000