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License agreements - MacroGenics (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Sep. 30, 2018
Dec. 31, 2017
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
License agreements            
Research and development     $ 292,527 $ 269,557 $ 893,719 $ 879,263
MacroGenics            
License agreements            
Upfront payment under license agreement   $ 150,000        
Research and development $ 10,000   6,300   23,700  
MacroGenics | Accrued and other liabilities            
License agreements            
Accrued and other liabilities $ 1,400 $ 1,100 $ 1,400   $ 1,400  
Minimum | MacroGenics            
License agreements            
Royalty payments on future global net sales (as a percent)   15.00%        
Maximum | MacroGenics            
License agreements            
Royalty payments on future global net sales (as a percent)   24.00%        
Development and Regulatory Milestones | Maximum | MacroGenics            
License agreements            
Additional milestone payments under the license agreement   $ 420,000        
Commercialization Milestones | Minimum | MacroGenics            
License agreements            
Additional milestone payments under the license agreement   $ 330,000