CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues:
Total revenues	$ 449,683	$ 381,534	$ 1,353,481	$ 1,092,060
Costs and expenses:
Cost of product revenues (including definite-lived intangible amortization)	24,795	22,036	67,757	57,120
Research and development	292,527	269,557	893,719	879,263
Selling, general and administrative	96,522	91,265	326,049	268,560
Change in fair value of acquisition-related contingent consideration	4,720	(16,343)	18,708	(1,914)
Total costs and expenses	418,564	366,515	1,306,233	1,203,029
Income (loss) from operations	31,119	15,019	47,248	(110,969)
Other income (expense), net	10,211	5,494	20,481	10,707
Interest expense	(405)	(204)	(1,188)	(6,527)
Unrealized gain (loss) on long term investments	(9,949)	23,045	(21,911)	(2,343)
Expense related to senior note conversions				(54,881)
Income (loss) before provision (benefit) for income taxes	30,976	43,354	44,630	(164,013)
Provision (benefit) for income taxes	1,800	7,300	4,200	(500)
Net income (loss)	$ 29,176	$ 36,054	$ 40,430	$ (163,513)
Net income (loss) per share:
Basic	$ 0.14	$ 0.17	$ 0.19	$ (0.81)
Diluted	$ 0.14	$ 0.17	$ 0.19	$ (0.81)
Shares used in computing net income (loss) per share:
Basic	212,627	206,796	212,172	202,399
Diluted	215,964	212,610	215,516	202,399
Product revenues, net
Revenues:
Total revenues	$ 367,715	$ 322,029	$ 1,067,744	$ 878,503
Product royalty revenues
Revenues:
Total revenues	61,923	44,487	165,592	108,477
Milestone revenues
Revenues:
Total revenues	20,000	15,000	120,000	105,000
Other revenues
Revenues:
Total revenues	$ 45	$ 18	$ 145	$ 80